此刻，全球精准医疗正站在历史转折点——当95%的现存基因数据基于碎片化短读长技术生成，我们是否要重新审视所有疾病机制与药物靶点？这项覆盖14类细胞、139组实验的里程碑研究，不仅为癌症治疗打开新维度，更预示着每个人未来都将拥有动态更新的"生命源代码手 ...

在这样的背景下，美国加利福尼亚大学圣地亚哥分校的研究人员开展了一项关于 DUBR（Dppa2 上游结合 RNA，也称为 linc00883）非编码 RNA 的研究。他们发现 DUBR 在人类结肠癌的发生发展中扮演着重要角色，这一发现为癌症研究开辟了新的道路。该研究成果发表在《Functional & Integrative Genomics》杂志上。

Spatial transcriptomics is a cutting-edge technique that characterizes gene expression within sections of tissue, such as ...

近年来，随着多组学技术的发展，人们对 HCC 的分子亚型有了更深入的了解。然而，代谢作为癌症的一个重要特征，其在 HCC 中的异质性尚未完全被揭示。肝脏作为人体最大的代谢器官，代谢紊乱与肝癌的发生密切相关。糖和脂质代谢在 HCC 癌细胞的信号传导、免疫逃逸和转移中发挥着关键作用。但以往大多数关于 HCC ...

The global marketplace for nanopore sequencing technologies is experiencing a remarkable phase of growth and innovation, as ...

An antibody discovery platform revealed more than 60 monoclonal antibodies specific to patients with alpha-gal syndrome, ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Get Instant Summarized Text (Gist) RNA sequencing has been clinically validated for whole-transcriptome analysis, enhancing genetic diagnostics for Mendelian diseases. This test, developed at ...

A research team led by Rice University’s Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a ...

Gannon University and Saint Vincent Hospital announced plans Wednesday to develop two new laboratories inside Gannon's ...