编者按：肝细胞癌（HCC）是一种高度异质性的恶性肿瘤，其治疗方案的选择对于患者的预后至关重要。阿替利珠单抗（atezolizumab）是一种免疫检查点抑制剂，能够阻断PD-L1与PD-1的结合，从而激活T细胞，增强抗肿瘤免疫反应。贝伐珠单抗（beva ...

引言与DNA不同，RNA不仅是基因表达的中介，还是细胞内多种复杂生物学过程的关键调控因子。近年来，RNA编辑作为RNA分子的一种天然修饰过程，引起了科学界广泛的兴趣。RNA编辑技术不仅能够精确调控基因表达，还为治疗各种遗传性疾病和复杂疾病提供了新的可 ...

Researchers studying gene expression have access to vast amounts of data from cells or tissues. This is thanks to advances in ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

近日，美国得克萨斯大学西南医学中心Yunsun Nam团队揭示了癌症相关突变如何通过改变METTL3-METTL14复合体对RNA甲基化（m6A）的特异性来促进肿瘤发生。研究发现，METTL14的R298P突变能够改变m6A的序列偏好，优先修饰含有GGAU ...

New gene therapy modalities, such as CRISPR guide RNA (single guide ribonucleic acid [sgRNA]) and messenger RNA (mRNA), ...

近日，上海交通大学医学院附属仁济医院心内科卜军课题组在《Nature Immunology》发表了研究论文“Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune ...

Rising demand for precision medicine & groundbreaking innovations in RNA sequencing drive growth in oncology, drug discovery, & personalized therapies. Akash Anand SNS Insider Pvt. Ltd 415-230-0044 ...

This study provides a valuable new resource to investigate the molecular basis of the particular features characterizing the pipefish embryo. The authors found both unique and shared gene expression ...

Scientists have discovered that some tiny segments of RNA thought to be junk instead have a functional role in suppressing ...

Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and ...

Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published ...