Thus, it is RNA pol II that transcribes the messenger RNAs, which serve as the templates for production of protein molecules. The first step in transcription is initiation, when the RNA pol binds ...

Like Mediator and TFIID, TFIIH is required for pol II transcription ... The Mediator complex as a master regulator of transcription by RNA polymerase II. Nat Rev Mol Cell Biol 2022, 23: 732 - 749.

mRNA transcription by RNA polymerase II (Pol II) is rapidly regulated in response to many different types of cellular stress, including heat shock. In response to heat shock in human cells, several ...

The process of transcription elongation by RNA polymerase II (Pol II), in which Pol II travels along DNA and synthesizes RNA from DNA, is essential for proper gene expression in all eukaryotic cells.

In Eukarya, RNA Polymerase II (Pol II) transcription is a highly regulated process, which is responsible for the transcription of all protein encoding genes. While the catalytic core of the Pol II ...

Anillin (ANLN), a mitotic protein that regulates contractile ring assembly, has been reported as an oncoprotein. However, the function of ANLN in cancer cells, especially in the nucleus, has not been ...

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in ...