RNA levels of the remaining 5,000–6,000 standard yeast genes vary over a wide range, but together represent ∼ 50% of all Pol II transcription 13, which gives an average value for a standard ...

为探究 RNA 聚合酶 II（Pol II）终止及重新起始机制，研究人员发现 RPB7 和 CTDP1 可稳定 Pol II 并助力其重新起始，为转录调控研究提供新视角。 在细胞的 “加工厂” 里，基因的转录过程就像一场精密的交响乐演奏，而 RNA 聚合酶 II（Pol II）则是这场演奏中至关重要 ...

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in ...