How inherited cancer risks can be used for effective personalized therapy
Mutations in BRCA2—a gene known to repair damaged DNA and suppress tumor formation—can predict an individual's predisposition ...
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RAD51 testing shows promise in personalized early breast cancer treatment
Developed in-house by Serra's laboratory, a test based on the detection of the RAD51 protein as a functional biomarker of homologous recombination repair (HRR) is currently being validated in the ...
Nature1y
Genetic Recombination
RPA has a higher affinity for ssDNA than Rad51, and it therefore can inhibit recombination by blocking Rad51's access to the single strand needed for invasion. In yeast, however, binding of Rad51 ...