Proteoglycans are glycosylated proteins which contain covalently attached highly anionic glycosaminoglycans (GAGs). Proteoglycans are present in different forms within different types of extracellular ...

A recent study has uncovered the essential roles of two proteoglycans, biglycan and decorin, in maintaining bone mass, water retention, and bulk/in situ mechanical competence. Through the use of ...

Our group focuses on mechanisms of neuronal development and plasticity. Based on neurite outgrowth assays, we have previously isolated, cloned, and produced as recombinant proteins two ligands of ...

Aplagon, a clinical stage biopharmaceutical company developing a first-in-class therapeutic for thrombo-inflammatory diseases, known as APAC, a heparin proteoglycan mimetic with antiplatelet and ...

Joseph Arboleda-Velasquez of Harvard Medical School praised the results. “Ye’s group has now provided compelling evidence showing increased binding affinity of ApoE3 Christchurch for tau and its ...