To characterize the contributions of individual amino acids to the structure or function of a protein, researchers have adopted directed evolution approaches, which use iterated cycles of ...

The 3-D structure of many proteins remained unavailable, and many important proteins could not be crystallized and analysed using x-ray crystallography. What’s more, even when a protein ...

maintaining cellular structure and function. However, when proteins become damaged, misfolded, or obsolete, they can lead to a range of diseases, from Alzheimer’s and Parkinson’s to cancer and ...

Our project focuses on analyzing how proteins assemble on membranes using Atomic Force Microscopy. With high-resolution, fast-scan Atomic Force Microscopy, we will directly visualize the structure and ...

For years, the standard way to study protein structure was to form a crystal and study the way that crystal diffracts X-rays. However, some proteins are difficult or even impossible to crystalize.

Although the rational protein design approach offers an increased possibility of beneficial alterations, it is not easy to accurately predict the sequence-structure-function relationship, particularly ...

the protein shell that plays an important role in genome replication and transcription. This motivated a team of researchers at Kyoto University to capture the first high-resolution structure of ...