Predicting a protein's structure from its amino acid sequence is a 'holy grail' for the structural biology community. In spite of decades of effort, it remains an extremely difficult problem both ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

The new model, called BaseFold, enables more reliable 3D structure predictions ... three-fold improvement in modelling accuracy for small molecule interactions with protein targets, according ...

protein structure determination, and computer-based modelling and simulation. We collaborate extensively in multidisciplinary initiatives. We acknowledge that our research and training activities take ...

solving a decades-long mystery by determining the first structure of the human protein PINK1 bound to mitochondria. First discovered more than 20 years ago, PINK1 is a protein directly ...

Scientists have for the first time looked deep into the protein structure that may determine our vision - and discovered that it is much more dynamic than previously thought. RBP3 not only changes ...

For infection to happen, the H protein first binds to a receptor on the target cell, and then the F protein changes its conformation to fuse the membranes. Advanced Search Home ...

Automate protein preparation and reduce inappropriate bias with Surflex-Dock's easy-to-use workflows. Surflex-Dock supports your 3D structure-based design efforts, allowing you to model ligands ...

Pancreas This releases enzymes into the intestines which break down carbohydrates, protein and lipids in ... called villi which have a tiny hair-like structure poking into the small intestine ...

Ribosomal functions beyond protein synthesis have been uncovered ... with the ribosomal tunnel and rearrange the internal structure, resulting in elongation stalling—known as "translation ...