Protein–protein interaction networks are the networks of protein complexes formed by biochemical events and/or electrostatic forces and that serve a distinct biological function as a complex.

The availability of large-scale protein-protein interaction data has led to the recent popularity of the study of protein interaction networks. Just as the enormous amount of available sequence ...

A Cornell University-led collaboration has uncovered the equipment that enables bacteria to survive exposure to antibiotics: ...

A novel geometric deep learning framework designs ligand-specific protein binders, enhancing therapeutic potential in cell therapies and synthetic biology.

Jumbo phages utilize a complex protein import system, with Imp1 as a key gatekeeper, to transport proteins into their ...

"Our idea was to engineer an interaction in which a small molecule causes two proteins to come together. Some approaches have focused on screening for such small molecules, but we wanted to design ...

Evolution has been fine-tuning life at the molecular level for billions of years. Proteins, the fundamental building blocks ...

Their environments—water, lipid membranes, or other condensed phases—are critical to their function, shaping their structure and interactions. Yet many modern protein-design methods ...

To uncover the sites of protein-DNA interactions at genome scale, Bing Ren, a former postdoctoral researcher in Young’s lab and now a gene regulation researcher at the University of California, San ...

Proteins' amino-acid sequences appear to guide their access to blob-like aggregates involved in many cell processes ...

Vimentin is a type III intermediate filament (IF) protein normally expressed in cells that develop into connective tissue, ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...