Although fast kinetics demonstrated that protein folding is not a simple two-state reaction, these experiments did not solve the problem of isolating and characterizing the structures of folding ...

The new focus on the protein folding problem, which includes a discussion on the kinetic consequences of rapid pre-equilibria and the relevance of transition state theory in light of advances in ...

"Now that we know the properties of protein cores under typical folding conditions, it's possible that protein core packing does not need to stop at 55%," said Alex Grigas, a Ph.D. candidate in O ...

In the fight against diseases like Alzheimer’s and Parkinson’s, scientists have long struggled to predict how certain ...

For those fuzzy on the details, here’s a progressive timeline that led to this monumental achievement. 1972: Anfinsen Presents the Protein-Folding Problem In science, it is often hard to pinpoint when ...

To learn about the problem and some potential solutions, the team began pursuing a group of stories that aimed to show a selection of possible solutions, from high-tech lab-grown meat to nomadic ...

Why do problems occur with a special variant of 'protein glues', the split inteins, that severely limit their use in producing proteins? A team has now answered this question.

Work done by Baker, Hassabis and Jumper has not only solved a decades-long protein folding problem, but it also helped usher in a new era of AI-based modeling to understand and design the fundamental ...