Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids ...

There are trillions of microbes in the gastrointestinal tract, and we are starting to learn more about the exact mechanisms ...

Scientists at Weill Cornell Medicine have uncovered a surprising new role for gut bacteria: producing bile acids that can ...

Nicholas Collins, assistant professor of immunology in medicine, both at Weill Cornell Medicine, are co-senior authors of the study. Primary bile acids are produced by the liver and released into the ...

Guo's lab, are the co-first authors of the study. Primary bile acids are produced by the liver and released into the gut, where diverse groups of bacteria work together to modify their chemical ...

Synthesized in the liver, bile acids play diverse roles in digestion and metabolism. However, when their processes are disrupted, disease can occur. Scientists seek advanced technologies to better ...

Amino acids such as glycine and taurine play a crucial role in liver and bile function. Glycine, a primary component of bile, ...

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NorUDCA (24-nor-ursodeoxycholic acid) is a chemically modified bile acid that has already shown promising results in the treatment of liver diseases such as primary ... of bile acids in the ...