Post-translational modifications are as, or even more, important than transcriptional regulation to finely tune circadian rhythms. Oscillations in period (PER) and cryptochrome (CRY) protein ...

Similarities to the post-translational modification phosphorylation suggest that AMPylation may be an important regulatory mechanism. Post-translational modifications are key steps in the ...

These studies revealed structural determinants for recognition of consensus SUMO modification sequences found within SUMO conjugated proteins. Reconstituting SUMO conjugation in vitro revealed ...

The research could contribute to the development of more effective anti-aging treatments in the future. The body's aging ...

The way the body ages could be more resilient than previously thought, a new study suggests.

The way the body ages could be more resilient than previously thought, a new study suggests.

Chromatin, the mix of DNA and protein that houses each cell's genome, is more resilient to aging than previously thought, suggests a study published in the Journal of the American Chemical Society by ...

As a shared facility of the Bindley Bioscience Center (BBC) in Discovery Park of Purdue University, the facility enables both targeted and global analysis of proteins, their post-translational ...