Thioredoxin, which is ubiquitous in cells, binds to TBD, triggering a conformational change that helps TBD enhance the polymerase’s processivity. “So, it was along the same lines as thinking about if ...

If processivity and fidelity are indeed unaffected ... The Pacific Biosciences system can also measure enzyme kinetics of single polymerase molecules. The authors presented data revealing that ...

She is passionate about making complex scientific concepts accessible to readers. View Full Profile. Learn about our Editorial Policies. Polymerase chain reaction (PCR) is a fundamental molecular ...

The role of XPB/Ssl2 dsDNA translocation processivity in transcription start-site scanning ... RD; Taatjes, DJ. TFIID enables RNA polymerase II promoter-proximal pausing. Mol Cell 2020, 78: 785 – 793.

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...