All COX2 inhibitors undergo oxidative drug metabolism by cytochrome P450 ... 50 is not only a potent inhibitor of platelet aggregation, but also interferes with processes leading to hypertension ...

resulting in low potential drug–drug interactions. When given as an intravenous bolus, immediate and full platelet inhibition of ADP-induced platelet aggregation was observed. The clinical ...

SAN DIEGO -- Treatment with an investigational oral inhibitor of Bruton's tyrosine ... only have short-term responses with drugs like rituximab and platelet counts can be incredibly unstable ...

Objective: To compare the effects of parecoxib sodium, an injectable prodrug of a cyclo-oxygenase-2-specific inhibitor, and ketorolac on platelet function and bleeding time in elderly individuals ...