There are three main signs of opioid overdose, the so-called "diagnostic triad." These include: a slow breathing rate (possibly down to four breaths a minute) constricted or "pinpoint" pupils ...

Symptoms of an active opioid overdose include slow or absent breathing, bluish skin, lips, or fingers, an unresponsive and/or limp body, and pin-point-sized pupils. In these life-or-death ...

“It’s the antidote to an opioid emergency ... Slow, shallow or absent breathing Pinpoint pupils: The person’s pupils (the dark circle in the center of the eye) may appear very small.