Phosphoinositides recruit proteins to distinct intracellular membranes. Now, the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive ...

It is well-established that in animal cells phosphoinositides play a central role in signal transduction by undergoing signal-stimulated hydrolysis to generate second messengers. However, the ...

Acidic phospholipids (especially phosphatidylserine and phosphoinositides) are the primary binding targets. Phospholipid-binding domains vary widely in their degree of ligand specificity.