Lyophilization (freeze-drying) is commonly utilized to support peptide stability. Removing water from peptide solutions might significantly reduce hydrolysis and deamidation rates. Lyophilized ...

You have full access to this article via your institution. In conclusion, we would like to emphasize two points: first, the importance of the cis conformation of peptide bonds in protein ...

Hydrolysis, or peptide bond cleavage via reaction with water, is theorized to be a primary degradation mechanism, particularly in aqueous solutions. Acidic or basic conditions may accelerate this ...

"A peptide bond is either cis or trans ... which are still susceptible to hydrolysis. "Collagen is all triple helices, from one end to the other," Raines says. "There's no weak link, and that's ...

Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide ... chain and endopeptidases attack an internal peptide bond, as in trypsin, chymotrypsin, pepsin, elastase and papain.