City of Hope researchers demonstrate proof of concept for a novel targeted therapy for pancreatic cancer, exploiting transcription-replication conflicts to combat treatment resistance.

Get Instant Summarized Text (Gist) Pancreatic cells can retain epigenetic marks linked to cancer without genetic mutations. These marks, observed in a transition state between normal and cancerous ...

Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates-only 10% after five years.

Pancreatic cells 'remember' epigenetic precancerous marks without genetic sequence mutations Date: April 4, 2025 Source: Johns Hopkins Medicine Summary: Scientists say they have found a pattern of ...

Metabolic and immune functions of GOT2 in pancreatic cancer cells. First, GOT2 catalyzes transamination reaction in ...

The cancer-fighting device safely triggers "potent" immune responses against hard-to-treat cancers, including metastatic ...

When the transitioning cells returned to their original identity as acinar cells, the scientists found that some of the epigenetic marks on pancreatic cancer-linked genes remained for at least ...

From 2000 to 2021, there was an increase in the incidence of pancreatic adenocarcinoma, which was seen in all age groups, ...

Scientists have developed a new method for identifying and classifying pancreatic cancer cell subtypes based on sugars found on the outside of cancer cells. These sugars, called glycans, help cells ...