In addition to cell-cycle regulation, mTOR plays a role in muscle hypertrophy following increased use through the growth factor IGF-1 and tumor suppressor PTEN. Blocking mTOR with drugs like rapamycin ...

Oncogenic activation of this pathway commonly occurs through activating mutations in the p110α isoform of PI3K or through loss of the PTEN ... AKT and mammalian target of rapamycin (mTOR ...

AKT inhibitor Truqap (capivasertib) has been cleared by NICE for use in combination with standard therapy fulvestrant for ...