Immunologic checkpoint blockade with antibodies against the programmed cell death protein-1 (PD-1) or its ligand (PD-L1) is an effective method for reversing cancer immunosuppression and thereby ...

Several studies have shown that detection of PD-L1 protein on tumour cells before treatment correlates with a positive response to checkpoint inhibitors. However, some patients who seem to be PD ...

发表了题为“TERC Suppresses PD-L1 Expression by Downregulating RNA Binding Protein HuR”的研究论文，揭示了TERC具有调控肿瘤细胞PD-L1表达水平的新功能。 癌细胞 ...

【导读】溶酶体靶向嵌合体（LYTAC）策略，为降解膜蛋白提供了一种非常强大的工具。然而，LYTACs（抗体-小分子共轭物）的合成具有挑战性。基于抗体的LYTACs穿透实体瘤的能力也很有限，尤其是穿越血脑屏障（BBB）的能力。在这项研究中，团队提出了一 ...

the proteins VEGF and either PD-1 or PD-L1. “It’s exactly that,” said Özlem Türeci, the CMO and co-founder of BioNTech. “I think that the anti-PD-1 or PD-L1 and VEGF concept can be a ...

Researchers reveal that gut microbiota influence the effectiveness of immune checkpoint inhibitors (ICIs) in cancer treatment ...

Programmed cell death protein 1 (PD-1) is an important immunosuppressive molecule in the human immune system, and programmed cell death ligand 1 (PD-L1) is its ligand protein molecule, both of ...

Piper Sandler initiated coverage of Merus (MRUS) with an Overweight rating and $84 price target The firm views the company’s EGFRxLGR5 ...

Atezolizumab (Tecentriq) plus chemotherapy after surgery did not improve survival in high-risk triple-negative breast cancer, ...

New research highlights the potential of the novel diagnostic tool iFRET to determine immunotherapy outcomes in stage 2 ...

The following is a summary of “Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s,” published in the January 2025 issue of Pulmonology by Mosleh et al. Sex-based ...