p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

作为一个编码p53蛋白的基因，TP53通过一系列机制保护我们的基因组稳定性，为细胞筑起了抵御癌变的第一道防线。p53是一种关键的转录因子 ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...