2006;40(11):2178-2186. The mechanism of action of fentanyl is best described by its agonist interaction with the opioid µ-receptor. These sites of interaction are primarily distributed throughout ...

When Narcan or naloxone is administered to someone with signs and symptoms of an opioid overdose, naloxone molecules travel through the body to the brain and attach to receptor sites in the brain ...

In the three aforementioned studies of epidural delivery of naloxone in combination with an opioid (fentanyl or morphine), the frequency of pruritus was decreased, with no reversal of analgesia noted.