RNA performs a given function itself (non-coding RNA, or ncRNAs). Human genome and transcriptome sequencing show that approximately 76 % of the genome is transcribed, but only 2 % of this codes ...

In addition cyclophilins play roles in inflammation and cancer and are already the target of several clinical drugs such as cyclosporin A. Surprisingly, this family has been robustly identified as ...

See how small bits of non-coding RNA target mRNA for destruction and regulate gene expression. Evidence has also shown that siRNA is involved in antiviral defense in certain plant and animal species.

Small nucleolar RNAs (snoRNAs) are non-coding RNA molecules whose role in gene ... Máté Varga, appears in NAR Genomics and ...

Ribonucleic acid (RNA) is a linear molecule composed of four types of smaller molecules called ribonucleotide bases: adenine (A), cytosine (C), guanine (G), and uracil (U). RNA is often compared ...

While the human genome project revealed an unexpectedly small fraction of the genome dedicated to protein-coding genes, the ENCODE and related projects revealed that at least 70% of the genome is ...

Non-coding RNA molecules, such as miRNAs (miRNAs ... RNAi is a powerful tool for studying gene function and has potential applications in therapeutics. RNA-based therapeutics, such as siRNAs, ...

The Galej Group at EMBL Grenoble has published new structural insights into minor spliceosome function ... non-coding genetic information—called introns—from the precursors of messenger RNA ...

Diederichs pooled the RNA samples from each group and analyzed the differences in gene expression between the two. One gene quickly stood out because its RNA was three times more abundant in ...

The rRNA molecules fold into complex secondary and tertiary structures, forming domains and motifs that are essential for ribosome function. The rRNA structures also provide binding ... This discovery ...