Mitochondria are central to energy production in cells, and their dysfunction is increasingly implicated in the aging process and the pathogenesis of ...

View Full Profile. Learn about our Editorial Policies. The paper Q. Zhang et al., “The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels,” ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes ...

Transmission electron microscopy (TEM) analysis revealed significant alterations in mitochondrial ... and induces oxidative stress in both differentiated and undifferentiated neuronal cells ...

Transforming growth factor-beta (TGF-β), a well-known morphogen, is recognized for its role in regulating growth and ...

CRISPRi screening revealed genes that affect neuron survival in iAssembloids but not in 2D monoculture. One gene, GSK3β, weakens neuron defenses against oxidative stress. ApoE4 astrocytes cause ...