Selecting an appropriate mouse model is one of the most important decisions ... immunodeficient and lack functional/mature T, B, and NK cells, and they have reduced macrophage and dendritic ...

Although elegant, this model was not verified ... Klein, E. & Wigzell, H. 'Natural' killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cell.

The researchers injected their newly engineered NK cells into an immunodeficient mouse model transplanted with human AML cells. FUT7-engineered NK cells were better at traveling to the bone marrow ...