This included three cultures from non-tumor nerve of subjects with NF1, leading to matched heterozygous SC lines for two of the subjects whose NF1-null Schwann cells also immortalized (ipNF95.11b ...

The NF1 gene codes for neurofibromin, a protein that acts as a tumour suppressor. Patients with the genetic disorder have a 30%-50% lifetime risk of developing PN, which are tumours that grow ...

All people have two copies of every gene – one copy inherited from each parent. The NF1 gene mutation is dominant, which means that only one of the two copies of the gene needs to have the mutation to ...

A key protein that could be responsible for brain ageing. Plus, researchers organize a day of action to #StandUpForScience.

The Phase II INSPIRE-NF1 trial (NCT06541847 ... an alternative to existing treatments targeting the mitogen-activated protein kinase kinase (MEK) pathway, which is involved in the growth of ...

Discover a study that used the Skindex-29 assessment to evaluate emotional wellbeing during selumetinib cycles.

Christopher L. Moertel, MD, University of Minnesota, discusses the trial data that helped get mirdametinib approved and what providers can do to keep measuring quality of life (QOL) improvements.