With greater clinical severity, they recommend adding a long-acting muscarinic receptor antagonists (LAMA) to ICS + long-acting b2 agonist (LABA) combination for 'triple therapy'. In even more ...

Stories about Datura are heard since childhood. One can be hypnotised if you take or inhale Datura. Scopolamine is also ...

The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily target dopaminergic signalling, the dysregulation of which has long been considered to have a ...

The drug – a selective muscarinic M4 receptor positive allosteric modulator ... an already-approved muscarinic antagonist designed to reduce M1/M4-related side effects in the peripheral nervous ...

University of California has described tropane derivatives acting as 5-HT2 and muscarinic receptor ligands reported to be useful for the treatment of psychiatric disorders, depression, ...

Muscarinic receptors are involved with neurotransmission via acetylcholine and glutamate, and are hypothesised to be dysfunctional in schizophrenia. Most drugs developed to treat schizophrenia to ...

Antagonizes of the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs including the bladder. Parasympatholytic activity reduces the tonus of smooth muscle in the ...

It has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3 receptors at the smooth muscle leading to ...

Xanomeline works by targeting two specific receptors in brain cells, M1 and M4, which are part of the muscarinic acetylcholine system. Trospium chloride helps by blocking xanomeline from ...

Many G-protein-coupled receptors (GPCRs ... a novel mechanism of GPCR activation and signalling by showing that a muscarinic acetylcholine receptor (mAChR) agonist can modulate both the ...