Cancer cells can poison attacking immune cells by filling them with defective mitochondria ― dampening the body’s defensive forces and helping the tumour to evade eradication 1. These findings ...

Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been thought to depend on the energy obtained through glycolysis ...

The study demonstrated that TIE1 localized to the mitochondria and its knockdown ... ING5 inhibits aerobic glycolysis of lung cancer cells by promoting TIE1-mediated phosphorylation of pyruvate ...

Researchers are shining a light on cancer cells' energy centers—literally—to damage these power sources and trigger widespread cancer cell death. In a new study, scientists combined strategies ...

enhancing oxidative stress and activating NF-κB to inhibit OXPHOS and boost glycolysis. Cancer cells in aerobic zones use lactic acid from CAFs to enhance OXPHOS, while hypoxic cancer cells ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

Welch, a professor from the University of Kansas Cancer Center (USA ... that despite their small size, mitochondria are widely known as the powerhouses of the cell, responsible for generating ...