Mitochondria, often seen as cellular powerhouses, play a surprising role in immune regulation. Researchers found that ...

We study the molecular mechanism of proteins involved in biological energy conversion and mitochondrial function/dysfunction (respiratory complexes I-V). We apply multi-scale computational approaches ...

While significant progress has been made in understanding the protein components of mitochondrial complexes, the role of certain conserved proteins remains enigmatic. Initially identified in ...

evolving compensatory mutations to maintain coadapted gene complexes. Researchers are now coming to appreciate that this has consequences for physiology and even macroevolution. Researchers have long ...

A novel mechanism that enables cells to maintain energy production even when their main power supply drops/fails has been ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes ...

A new study uncovers a novel mechanism through which brown fat is transformed into heat, offering protection against ...

Analogous to chromosomal DNA that wraps around histone proteins to fit in the nucleus, mtDNA molecules are compacted into mtDNA-protein complexes termed nucleoids. Mitochondrial nucleoid proteins ...

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen ...