We are driven to understand the signals regulating tissue-specific autophagy signalling in mammalian health and disease. Understanding the physiological regulation and significance of selective ...

Researchers at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena have discovered a new function of the DNA ...

A recent study published in Magnetic Resonance Letters has revealed for the first time the interaction mechanism between the mitochondrial proteins ...

In AD, amyloid-beta (Aβ) disrupts mitochondrial Ca 2+ homeostasis by enhancing Ca 2+ uptake via MCU and impairing efflux through NCLX. These changes lead to ROS accumulation, energy depletion ...

Cystinuria is the most common inheritable cause of kidney stone disease, characterized by impaired reabsorption of cystine and dibasic amino acids in ...

Prince Frederik of Luxembourg has died at the age of 22 from POLG mitochondrial disease, a rare genetic disorder that he was born with, his family announced. Frederik de Nassau died in Paris on ...

Cystinuria is the most common inheritable cause of kidney stone disease, characterized by impaired reabsorption of cystine ...