Mitochondria are commonly found as extended reticular webs whose overall morphology depends on frequent fission and fusion of mitochondrial tubules. These processes require distinct GTP-binding ...

This fragmentation was dependent on both the RING domain of MAPL and the presence of the mitochondrial fission GTPase dynamin-related protein-1 (DRP1). Interestingly, however, when the authors ...

Interestingly, CED-3 can cleave DRP-1, which appears to be important for DRP-1's proapoptotic function, but not its mitochondria fission function. Our findings demonstrate that mitochondria dynamics ...

In addition to targeting mitochondrial fission proteins by genetic manipulation in the lab, the team also identified a ...

Central to the discussion is the concept of mitochondrial quality control, including mitochondrial dynamics (fusion/fission balance) and mitophagy. The review presents evidence linking aberrations in ...

We started with the hypothesis that TBI might pathologically impair the balance of mitochondrial fission and fusion. The normal homeostatic balance of mitochondrial fission and fusion is how ...