Researchers at the University of Cologne found that mitochondrial dysfunction leads to early skeletal aging by disrupting cartilage metabolism. The study identified maladaptive metabolic shifts, ...

Researchers at the University of Gothenburg have identified a small molecule, PZL-A, that restores function in the defective ...

The POLG gene regulates the production of DNA polymerase gamma, an enzyme that copies mitochondrial DNA. Without it, the mitochondria cannot function normally and, as a result, fail to provide the ...

We now show that NT induces release of extracellular mitochondrial DNA (mtDNA) that could act as "autoimmune" trigger. We further show that serum from young autistic patients contains mtDNA (n ...

Mitochondrial DNA is a remnant from the organelle's forebears ... "Stress makes mitochondria more likely to release pieces of their DNA and these pieces can then 'infect' the nuclear genome ...

They found that when mitochondria got too big, their mitochondrial DNA leaked out into the cytosol, the fluid that fills up the space inside cells. This triggered an increase in the release of ...

When the mechanisms that replicate or repair mitochondrial DNA (mtDNA) fail, it can cause a wide range of syndromes for which there are few to zero existing treatment options. One of the causes of ...

The POLG gene regulates the production of DNA polymerase gamma, an enzyme that copies mitochondrial DNA. Without it, the mitochondria cannot function normally and, as a result, fail to provide the ...

Caption The study identified a drastic bottleneck, in which only seven to ten of the mother's thousands of copies of mitochondrial DNA get passed on to each child. Because of the timing of the ...

Along the way, some genes simply vanished, while the rest migrated to the nucleus before we evolved from our primate ancestors. Since then, mitochondrial DNA (mtDNA) has been thought to remain ...