Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial defects, however, ...

Mitochondrial damage is common in metabolic diseases like Diabetes, affecting insulin production and function in patients. Diabetics’ insulin-producing β-cells have abnormal mitochondria, impairing ...

Two import pathways that direct proteins into the mitochondrial inner membrane and matrix have been known for many years. The identification of numerous new transport components in recent ...

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

Type 2 diabetes is a condition where the body cannot produce enough insulin or does not use insulin effectively. Insulin is a ...

Mitochondrial defects are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use the insulin produced ...

For instance, mtDNA (or other extracellular mitochondrial components not measured in this study) could activate TLRs on immune or glial cells to release pro-inflammatory cytokines, such as IL-6 ...

Mitochondria are responsible for creating energy, which fuels cells and keeps them functioning. However, mitochondrial ...

Researchers have discovered that mitochondrial dysfunction plays a crucial role in diabetes, offering new hope for potential ...

University of Michigan researchers found that mitochondrial dysfunction triggers a stress response that prevents pancreatic β ...