This adds to the growing body of work, from mouse and fly models, implicating lipid metabolism in neurodegeneration, particularly AD,” Amita Sehgal, Perelman School of Medici ...

Microglia’s stress response drives toxic lipid production linked to Alzheimer’s progression. Blocking stress or lipid pathways reversed synapse loss in preclinical Alzheimer’s models. Findings ...

These microglia then mount an inflammatory response ... More information: Yajuan Li et al, Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK, Cell Metabolism ...

Lipid deposits (green) in brain immune cells (red) from mice with Alzheimer’s-like disease all but disappear (right) after the mice are treated with an experimental drug. Researchers at ...

Caption Pictured are cells from a MIEL1 mutant Arabidopsis seed with neutral lipids shown in magenta and a lipid droplet coat protein shown in green. Traver and Bartel used genetics and microscopy ...