This adds to the growing body of work, from mouse and fly models, implicating lipid metabolism in neurodegeneration, particularly AD,” Amita Sehgal, Perelman School of Medici ...

The research team discovered that activation of this stress pathway, known as the integrated stress response (ISR), prompts microglia to produce and release toxic lipids. These lipids damage ...

These microglia then mount an inflammatory response ... More information: Yajuan Li et al, Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK, Cell Metabolism ...

This discovery opens the door for targeted therapies to slow or stop Alzheimer’s progression by modulating microglial activity. Microglia’s stress response drives toxic lipid production linked to ...

Lipid deposits (green) in brain immune cells (red) from mice with Alzheimer’s-like disease all but disappear (right) after the mice are treated with an experimental drug. Researchers at ...

Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV Jr, Walther TC. Seipin forms a flexible cage at lipid droplet formation sites. Nat Struct Mol ...

Caption Pictured are cells from a MIEL1 mutant Arabidopsis seed with neutral lipids shown in magenta and a lipid droplet coat protein shown in green. Traver and Bartel used genetics and microscopy ...