Figure 1: Plots of isotropic B factors calculated for protein structures solved in both the native and methylated states. We showed in this large-scale study that reductive methylation of proteins ...

DNA methylation is one of several epigenetic ... In an interestingly coordinated process, proteins that bind to methylated DNA also form complexes with the proteins involved in deacetylation ...

The protein is the MCJ (Methylation-controlled J) protein, and it was highlighted by a team led by researchers from the Spanish National Cancer Centre (CNIO). They also found a previously undiscovered ...

Metabolism can change when an acetyl group attaches to lysine in a mitochondrial protein (acetylation). The addition of a methyl group to histone peptides (methylation) regulates gene expression. And ...

View Full Profile. Learn about our Editorial Policies. “This study really provides the first look at how methylation and epigenetic modification of the DNA eventually have an impact on the protein ...

In addition to finding that H3 lysine-4 methylation is important for activation of master regulator genes, McKay and colleagues also found that it plays a key role in turning "off" the protein ...

Yoshiki Ochiai, the paper's first author and Ph.D. student in the Protein Engineering and Evolution Unit, tried to improve RNA methylation activity of a bacterial non-site-specific DNA ...

The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...

A DNA methylation test is one of several noninvasive biomarkers test under investigation for the early diagnosis of bladder cancer.

A urinary DNA methylation test demonstrated a high sensitivity for detecting high-grade or invasive bladder cancer, ...

A little-known mouse protein disrupts cancer-causing chemical ... need to develop new approaches to therapeutically block DNA methylation abnormalities," says corresponding co-author Stephen ...