Families of methyl- or histone-binding proteins decipher the regulatory information that is encoded by DNA methylation and histone marks. The presence of histone variants adds further complexity.

Epigenetic changes can switch genes on or off and determine which proteins are transcribed ... treatments aim to alter either DNA methylation or histone acetylation. Inhibitors of DNA methylation ...

Methylation is one of the more prevalent ... experimental animal model system they could use to study the role of histone proteins in regulating genes. For this study, researchers examined ...

Metabolism can change when an acetyl group attaches to lysine in a mitochondrial protein (acetylation). The addition of a methyl group to histone peptides (methylation) regulates gene expression. And ...

Our group retains an interest in the areas of structure-function studies of RNA interference mediated by siRNA pathway, and on post-translation histone and DNA modifications impacting on epigenetic ...