Long read sequencing reveals more genetic information while cutting time and cost of rare disease diagnoses
One in every 10 people worldwide is impacted by a rare genetic disease but about 50% of them remain undiagnosed despite rapid increases in genetic technology and testing. Even when a person does have ...
Long-lived men healthier than female counterparts: study
Chinese researchers have recently discovered that unique DNA methylation characteristics in long-lived men grant them better health compared to female ...
BioTechniques9d
Long-read sequencing expedites rare disease diagnoses
LRS is a next-generation sequencing method that can read longer strands of DNA as well as provide phasing and methylation information. “Rare diseases are something that people have been struggling to ...
technologynetworks13d
Long Read Sequencing Speeds Up Rare Disease Diagnosis
UC Santa Cruz researchers showcase how long-read sequencing can diagnose rare genetic diseases in days instead of years.
Hosted on MSN6mon
DNA Sequence Variants Drive Link Between Methylation and Gene Expression
The relationship between DNA methylation and gene expression is driven by sequence variants, according to a recent study conducted by researchers at deCODE Genetics, an Amgen subsidiary.
technologynetworks20d
How SPRQ Chemistry Is Breaking Barriers in DNA Sequencing
The SPRQ chemistry brings three major benefits: 4x lower DNA input, 33% higher sequencing yield and more accurate direct methylation detection. With only 500 ng of DNA needed for a human whole genome, ...
Medical Xpress25d
DNA methylation mediates the link between childhood adversity and depression, study suggests
Dunn, recently carried out a study exploring how DNA methylation, an epigenetic modification ... gene activity without altering the DNA sequence." Recent research gathered evidence suggesting ...
GEN12d
Long-Read Nanopore Sequencing Improves Rare Disease Diagnosis
Long read sequencing revealed more genetic information in cases of 42 patients with rare diseases while cutting time and cost of diagnoses.
eLife10d
Early Diagnosis and Prognostic Prediction of Colorectal Cancer through Plasma Methylation Regions
The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...