However, DNMT1 rapidly scans DNA and deposits methyl groups on newly synthesized DNA, opposite methyl groups present on the old DNA strand. This results in faithful replication of methylation ...

DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...

The rate of biological aging indicates the discrepancy between chronological age and biological age, that is, whether a ...

For instance, in normal, healthy mice, the agouti genes are kept in the "off" position by the epigenome, which attaches methyl groups to the corresponding regions of DNA, resulting in the DNA's ...

Humans do not always age biologically at the same rate as their chronological age. Faster biological aging compared to chronological age has been linked to higher risks of disease and mortality.