总的来说，搔抓与免疫反应的关系揭示了皮肤免疫疾病治疗的新方向。通过深入理解神经免疫交互作用，未来的研究有望开发出更加精确的治疗方法，不仅改善患者的临床症状，还可能从根本上恢复皮肤免疫功能。这一全新的治疗思路为过敏性皮肤病的管理带来了前所未有的希望，未 ...

接下来，这个研究团队发现，抓挠会导致痛觉神经元释放一种名为P物质的化合物。反过来，P物质会激活肥大细胞，而肥大细胞是炎症的关键协调者，通过招募中性粒细胞来驱动瘙痒和炎症。

IT has been demonstrated that, besides heparin and histamine, mast cells contain serotonin (5-hydroxytryptamine, 5-HT) 1–3. However, serotonin-containing mast cells, having been found ...

They noticed that at scratched sites, pain-sensing neurons released a potent nervous-system messenger called substance P. Substance P activated key white blood cells called mast cells, which are ...

Food allergy, or the aggressive immune system reaction following the consumption of a certain food or food ingredient, typically involves immunoglobulin E (IgE) antibodies and can be potentially ...

Food allergies can be life-threatening due to the rapid and exaggerated immune response. While mucosal mast cells (MMCs) are excessively proliferated during food allergies, the precise mechanisms that ...

A new case report was published in Oncoscience's Volume 12 on February 4, 2025, titled “Breaking point: Systemic mastocytosis manifesting as severe osteoporosis.” ...

Scientists have now shown why it may not be a good idea to scratch an itchy rash, even though it feels good. This research ...

Scratching an itchy rash worsens inflammation by triggering pain-sensing neurons and activating mast cells, creating a ...

The MAD cohort also saw adverse events such as hair loss and reductions in hemoglobin and neutrophil counts. These side ...