More information: Emily M. King et al, Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific ...

More importantly, they identified specific macrophage subpopulations that are critical for resolving MASH and liver fibrosis in which accumulating scar tissue impairs the organ's ability to ...

The team revealed distinct phases where waves of immune responses give way to lung fibrosis—scarring of ... via signals from disease-associated macrophage populations. The researchers hope ...

An early inflammatory event triggers the onset of an abnormal reparative process, leading to fibrosis. Controlling the M2 macrophage population represents a promising therapeutic strategy ...

(B, C) Quantitative reverse transcription-PCR and Western blot analysis of lung Arg1 in S1pr3-C and S1 S1pr3 knockdown ameliorates bleomycin-induced pulmonary fibrosis by reducing macrophage M2 ...