MLL1 is rearranged in patients with acute leukaemia and leads to the deregulated expression of HOX genes ... gene transcription and therefore MLL-mediated transformation and leukaemogenesis.

After demonstrating that the DNA binding patterns for MLL differ in lymphoid and myeloid leukemias, the group wanted to know how the abundance of MLL protein influenced target gene expression. They ...

A plasmid with the human ubiquitin C promoter driving expression of firefly luciferase ... To amplify the MLL-AF9 breakpoint region the following primer pair was used: forward – 5 ...

MLL protein is a type of enzyme that modifies certain proteins in our DNA which at times could lead to blood cancer which is a common cancer in children making up 28% of all cases. A group of ...