Autophagy targets portions of cytoplasm, damaged organelles and proteins for lysosomal degradation and has crucial roles in development and disease. This issue presents a series of specially ...

We hypothesized that the reason for this reduction of EV cargoes in nwk mutants is that cargoes are being sent to the lysosome for degradation rather than being sent out of the cell in EVs. We tested ...

(4) Depolarised mitochondria undergo morphological remodelling to squeeze their matrix to form donut-shaped mitochondrial spheroids and acquire lysosomal contents for possible degradation.

These molecules, upregulated in cancer cells, are excreted through a surprising mechanism—lysosomal exocytosis. Researchers published their results in the Journal of Cell Biology on January 3 ...