VEGF-D knockdown in 468 LN cells resulted in a marked ... tumor-associated lymphangiogenesis and angiogenesis and spontaneous metastasis to the lymph nodes and the lungs in this tumor model ...

The lymphatic circulation is also a key player in disease processes such as cancer metastasis ... FGF-2 stimulates both lymphangiogenesis and angiogenesis. FGF-2 upregulates VEGF-C expression ...

In addition to being potential targets for inhibiting tumour metastasis, factors implicated in tumour lymphangiogenesis and the specific molecules found on the activated lymphatic endothelium may ...

Lymphangiogenesis, i.e. the development of lymphatic vessels, is generally associated with a poor prognosis, as it favours the spread of metastases to other organs. By studying the cells that make ...

The functional lymphatic vessels transport inflammatory lymph-carrying inflammatory cells, catabolic factors and cytokines to the draining LNs and promote lymphangiogenesis, leading to an ...

When a tumor develops, it creates a structure around itself called the tumor stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges. Lymphangiogenesis ...