Phys.org on MSN17d
Researchers successfully deliver mRNA-based drugs to the intestine – without passing through the liver
By simply altering the composition of the nanoparticles, the researchers demonstrated that mRNA-based drugs can be directed straight to target cells, avoiding the liver. The groundbreaking Tel Aviv ...
C&EN2y
Mitigating Drug-Induced Liver Injury—Assessing Mitochondrial Toxicity and Reactive Metabolism
Drug-induced liver injury (DILI) is common because it can be caused by different pharmacological agents from nearly all classes of medications, including hepatotoxic drugs, anesthetics, anticancer ...
Medical Xpress1mon
Decades-old allergy drug shows potential for treating liver complications in rare genetic disease
They also showed in EPP liver cell culture models that the histamine pathway promotes porphyrin accumulation, which is blocked by the over-the-counter antihistamine drug classes that treat allergy ...
C&EN2y
Mitigating Drug-Induced Liver Injury—Assessing Transporter Liabilities and Bioactivation Transcriptomics, Part 2
Derisking of drug-induced liver injury (DILI) continues to be a challenge for pharmaceutical scientists. Join Michael Hafey, Principal Scientist at Merck, as he discusses how to utilize a two-tiered ...