These mice exhibit a severe bleeding tendency and a leukocyte adhesion defect reminiscent to the phenotype in LAD-III patients. Kindlin-3 belongs to a family of three cytoplasmic proteins ...

About Leukocyte Adhesion Deficiency Type II (LAD-II ... moderate to severe neurodevelopmental retardation. The genetic defect in LAD-II patients has been shown to be various mutations in ...