The detailed sequence of events following ECM binding to the integrin is not known, but the β-subunit cytoplasmic domain interacts directly with talin, and talin interacts with both vinculin and ...

In human JEB, besides mutations of the laminin-5 gene, mutations in type XVII collagen and α6β4-integrin genes have been reported 25. Mutations within either subunit of the α6β4-integrin not ...