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生物通
27 天
LRRK2 G2019S 基因敲入小鼠的帕金森病研究新发现:咖啡因的潜在治疗价值
为探究 LRRK2 G2019S 敲入(KI)小鼠能否模拟 LRRK2 帕金森病(PD),研究人员用脂多糖(LPS)处理小鼠,发现 LPS 未致多巴胺能神经元丢失但激活了星形胶质细胞,且咖啡因可缓解,这为 PD 治疗提供新方向。 帕金森病(Parkinson’s disease,PD),这一神秘的神经退行性 ...
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