Kupffer cells, hepatocytes, platelets, and leukocytes. Endothelial cells are also likely to participate in activation, both by production of cellular fibronectin and via conversion of transforming ...

Through a unique fabrication technique, "islands" of human hepatocytes are cultured alongside stromal and Kupffer cells in a precise ratio. This setup replicates the liver's physiological ...

In the liver, senescence impacts key cell types including hepatocytes, liver sinusoidal endothelial cells, and Kupffer cells, and contributes to chronic liver diseases such as fibrosis ...

On the contrary, there is minimal expression of class I HLA antigens on hepatocytes, which favors decreased antigenicity. It is also thought that donor Kupffer cells may be replaced with host ...

3D validated cells Duo-culture Primary human hepatocytes + Kupffer Cells HBV, DILI, Immune-mediated toxicity PhysioMimix OOC, Liver plates, 3D validated cells Tri-culture Primary human hepatocytes ...

Alcohol metabolism in hepatocytes generates reactive oxygen ... liver cells and trigger immune responses. Activation of Kupffer cells (liver-resident macrophages) and hepatic stellate cells ...

Non-parenchymal cells like hepatic stellate cells (HSCs), Kupffer cells (KCs), and liver sinusoidal endothelial cells (LSECs) play a key role in fibrosis development. These cells are involved in ...