Knockout technology is extraordinarily powerful ... Peters, L. L. et al. The mouse as a model for human biology: a resource guide for complex trait analysis. Nature Rev. Genet.

The current 5-year funding period of KOMP2 is creating and characterizing knockout mice for 1,227 genes. All mouse model production and phenotyping data generated by the BCM KOMP2 are available ...

A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

Today, the mouse is by far the most common research mammal in the world. Initially, the focus was on the study of cancer, but the mouse is now used as a model by scientists of almost all biological ...

Taconic Biosciences prioritizes accessibility and efficiency in preclinical research. Unlike other providers, Taconic does ...

A research team from the International Research Center for Medical Sciences (IRCMS) at Kumamoto University has identified a ...

Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results from a combination of higher Pol II turnover and lower transcription ...

The team then edited the mouse genome using a streamlined strategy that combined three editing technologies: RNP-mediated knockout ... but it is also a living model for studying cold-climate ...