Kinases are enzymes that catalyze the addition of a phosphate group (PO43−) to substrates, usually proteins. The phosphate generally comes from adenosine triphosphate (ATP). Kinases and ...

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits.

“The genome of most mammals, including humans, contains about 500 protein kinases that regulate nearly all aspects of our biology,” explained Dr. Notredame. “These kinases are major targets ...